Hailing from Transvaal, South Africa, Nkululeko Serame (Mafinki Serame) is an off-spinner and a handy lower-order batsman. Serame made his first-class debut in 2006 for KwaZulu-Natal; a match that his team won by 10 wickets. The off-spinner's contribution in that match was only two wickets but as a debutant it was a match for him to remember.

Nkululeko was also a part of the South African Academy that toured Zimbabwe in August 2007 where he picked his career best List A figures of 5/25 against the Minnows.

Although Serame has a good first-class record, he has played more number of List-A games as compared to the three-day contest. An advocate of the High Court of South Africa, Serame currently represents Boland across all three formats.