At a raw age of 18, Harshad Khadiwali made his first-class debut and only in his first ever innings of Ranji Trophy, the youngster showed nerves of steel with a composed knock of 40. Khadiwale was unfortunately run-out in that match; else it could have been a much better debut for him. Harshad's maiden first-class century came against Tamil Nadu during 2007-08 season and as a result of few impressive knocks that season he was also picked up in the West Zone squad for Duleep Trophy. He was also a part of Pune Warriors in Indian Premier League 2011 but hardly got any chances due to the presence of other talented youngsters in the squad.

Harshad Khadiwale played 80 first-class matches and had a highest score of 242 and runs in excess of 5000 to boast about. However due to a dip in form towards the later stages of his career, he had a series of low scores. For the same reason, he was eventually dropped from the team and he played his last first-class game against Karnataka in November 2017.